Highly Sensitive and Specific Detection of Mobilized Colistin Resistance Gene <i>mcr-1</i> by CRISPR-Based Platform
Lin Gong, Zhengjiang Jin, Ernan Liu, Fei Tang, Fengyun Yuan, Jiansheng Liang, Yimei Wang, Yimei Wang, Xiaoli Liu, Yi Wang, Yi Wang
Abstract
This study promises a rapid and accurate assay (RPA-CRISPR/Cas12a) for the surveillance of mcr-1 gene, which causes the efficacy loss of colistin in clinical treatments. In addition, the established method is fit for “on-site” surveillance especially.
Topics & Concepts
CRISPRColistinRecombinase Polymerase AmplificationPlasmidGenePolymerase chain reactionBiologyMolecular biologyComputational biologyMicrobiologyGeneticsAntibioticsAntibiotic Resistance in BacteriaCRISPR and Genetic EngineeringVibrio bacteria research studies