Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking
Sarah A. Flowers, Kristina A. Thomsson, Liaqat Ali, Shan Huang, Yolanda Mthembu, Suresh C. Regmi, Jan Holgersson, Tannin A. Schmidt, Ola Rolfson, Lena Björkman, Martina Sundqvist, Anna Karlsson, Gregory D. Jay, Thomas Eisler, Roman Krawetz, Niclas G. Karlsson
Abstract
glycans (T-antigens) and Tn-antigens. These data suggest a defect in crosslinking of surface-active molecules in OA and provide novel insights into OA molecular pathology.
Topics & Concepts
GlycoproteinMucinOsteoarthritisChemistryGlycosylationGlycanSynovial fluidProteoglycanCell biologyChinese hamster ovary cellBiochemistryBiologyMedicineExtracellular matrixReceptorPathologyAlternative medicineGalectins and Cancer BiologyCell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research