Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
Julia M. D. Grandjean, Aparajita Madhavan, Lauren Čech, Bryan O. Seguinot, Ryan J Paxman, Emery Smith, Louis Scampavia, Evan T. Powers, Christina B. Cooley, Lars Plate, Timothy Spicer, Jeffery W. Kelly, R. Luke Wiseman
Topics & Concepts
ProteostasisUnfolded protein responseXBP1Cell biologyEndoplasmic reticulumBiologyEndoplasmic-reticulum-associated protein degradationSignal transductionRNA splicingBiochemistryRNAGeneEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms