Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
Qingke Li, Chen Qu, Paul C. Klauser, Mengyuan Li, Feng Zheng, Nanxi Wang, Xiaoying Li, Qianbing Zhang, Xuemei Fu, Qian Wang, Yang Xu, Lei Wang
Topics & Concepts
Covalent bondSmall moleculeHistidineBiologyIn vivoBiochemistryPlasma protein bindingProtein–protein interactionNon-covalent interactionsIn vitroCombinatorial chemistryAmino acidPharmacologyBiophysicsChemistryMoleculeGeneticsOrganic chemistryHydrogen bondMonoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy researchPeptidase Inhibition and Analysis