Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis
Zhaolan Hu, Cong Luo, P. Hurtado, Hui Li, Shuang Wang, Bo Hu, Junmei Xu, Liu Yang, Shiqing Feng, E. Hurtado-Perez, Kang Chen, Xin‐Fu Zhou, Chang-Qi Li, Ru‐Ping Dai
Abstract
The findings suggest that proBDNF from immune cells promotes the immunopathogenesis of MS. Monoclonal Ab-proB may be a promising therapeutic agent for treating MS.
Topics & Concepts
Multiple sclerosisExperimental autoimmune encephalomyelitisMedicineImmune systemPeripheral blood mononuclear cellNeurotrophic factorsBrain-derived neurotrophic factorImmunologyProinflammatory cytokineMonoclonal antibodyCentral nervous systemAntibodyReceptorBiologyInflammationIn vitroInternal medicineBiochemistryNerve injury and regenerationMultiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms