<sup>14</sup> N– <sup>1</sup> H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
Marvin Grüne, Robert Luxenhofer, Dinu Iuga, Steven P. Brown, Ann‐Christin Pöppler
Abstract
H through-space proximities. In this way, the overall complexity can be narrowed down to specific N-containing environments. The results from the experiments presented here represent a valuable puzzle piece, which helps to improve the structural understanding of drug-polymer formulations. It can be straightforwardly combined with complementary NMR spectroscopic experiments and other analytical techniques.
Topics & Concepts
Amorphous solidPolymerCrystallographyMaterials scienceNuclear magnetic resonance spectroscopyAnalytical Chemistry (journal)Nuclear chemistryPhysicsChemistryNuclear magnetic resonanceOrganic chemistryAdvanced NMR Techniques and ApplicationsSolid-state spectroscopy and crystallographyX-ray Diffraction in Crystallography