Copper-catalyzed asymmetric allylic C–H amination of alkenes using <i>N</i>-arylhydroxylamines
Siva Murru, Bhanudas Dattatray Mokar, Ramesh Bista, Dominique Harakat, Jean Le Bras, Frank R. Fronczek, Kenneth M. Nicholas, Radhey S. Srivastava
Abstract
The first Cu-catalyzed asymmetric allylic C–H amination of alkenes with <italic>N</italic>-aryl hydroxylamines has been developed. Metal-complexes isolation, ESI-MS analysis and the DFT calculations provided key insights on mechanistic pathway.
Topics & Concepts
ChemistryAllylic rearrangementAminationCatalysisCopperMetalMedicinal chemistryArylOrganic chemistryCombinatorial chemistryAlkylSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis