A Core Genome Multilocus Sequence Typing Scheme for Streptococcus mutans
Shan Shan Liu, Xiaoliang Li, Zhenfei Guo, Hongsheng Liu, Yu Sun, Yudong Liu, Qinglong Wang, Shengkai Liao, Kai Zhang
Abstract
Streptococcus mutans is regarded as a major pathogen responsible for the onset of dental caries. S. mutans can transmit among people, especially within families. In this study, we established a new epidemiological approach to S. mutans classification. This approach can effectively differentiate among closely related isolates and offers superior reliability relative to that of the traditional MLST molecular typing method. As such, it has the potential to better support effective public health strategies centered around this bacterium that are aimed at preventing and treating dental caries.
Topics & Concepts
Multilocus sequence typingTypingStreptococcus mutansPhylogenetic treeBiologyGenomeWhole genome sequencingPopulationGeneticsComputational biologyMicrobiologyGenotypeGeneMedicineBacteriaEnvironmental healthOral microbiology and periodontitis researchStreptococcal Infections and TreatmentsInfective Endocarditis Diagnosis and Management