Enaminone-directed ruthenium(<scp>ii</scp>)-catalyzed C–H activation and annulation of arenes with diazonaphthoquinones for polycyclic benzocoumarins
Sudeshna Mondal, Chandan Kumar Giri, Mahiuddin Baidya
Abstract
The weakly coordinating enaminone functionality has been leveraged for a C-H bond activation strategy under ruthenium catalysis and employed in the regioselective annulative coupling of arenes with diazonaphthoquinones, offering polycyclic benzocoumarins in very high yields. The enaminone motif plays a dual role and the protocol operates through a Ru(II)/Ru(IV) catalytic pathway which is amenable to the diversification of various pharmacophore-coupled substrates.
Topics & Concepts
RutheniumRegioselectivityCatalysisAnnulationChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms