Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry
Pantaleo Musci, Marco Colella, Michael Andresini, Andrea Aramini, Leonardo Degennaro, Renzo Luisi
Abstract
O-ring) were also evaluated. New chemical space has been explored and new structural motifs such as ABB-aziridines or spiro azetidine-oxazetidines are also reported.
Topics & Concepts
ChemoselectivityReactivity (psychology)Ring (chemistry)Chemical spaceChemistryAzetidineContinuous flowSpace (punctuation)StereochemistryCombinatorial chemistryComputer scienceOrganic chemistryPhysicsCatalysisDrug discoveryOperating systemPathologyMechanicsAlternative medicineBiochemistryMedicineSynthesis and Catalytic ReactionsInnovative Microfluidic and Catalytic Techniques InnovationAsymmetric Hydrogenation and Catalysis