A founder event causing a dominant childhood epilepsy survives 800 years through weak selective pressure
Bronwyn E. Grinton, Erandee Robertson, Liam G. Fearnley, Ingrid E. Scheffer, Anthony G Marson, Terence J. O’Brien, William Owen Pickrell, Mark I. Rees, Sanjay M. Sisodiya, David J. Balding, Mark F. Bennett, Melanie Bahlo, Samuel F. Berkovic, Karen Oliver
Topics & Concepts
PenetranceFounder effectHaplotypeGeneticsEpilepsyBiologyPopulationExome sequencingEpilepsy syndromesGenetic heterogeneityExomePhenotypeEvolutionary biologyAlleleMedicineGeneNeuroscienceEnvironmental healthGenomics and Rare DiseasesEpilepsy research and treatmentGenetics and Neurodevelopmental Disorders