miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn(II)-Protoporphyrin IX-Loaded Metal–Organic Framework Nanoparticles
Pu Zhang, Yu Ouyang, Yang Sung Sohn, Michael Fadeev, Ola Karmi, Rachel Nechushtai, Ilan Stein, Eli Pikarsky, Itamar Willner
Abstract
. This activates the interhairpin hybridization chain reaction and leads to the assembly of highly fluorescent Zn(II)-PPIX-loaded G-quadruplex chains. The miRNA-guided fluorescent chains allow selective imaging of cancer cells. Moreover, PDT with visible light selectively kills cancer cells and tumor cells through the formation of toxic reactive oxygen species.
Topics & Concepts
Protoporphyrin IXPhotodynamic therapyCancer cellFluorescenceChemistryIntracellularFluorescence-lifetime imaging microscopyBiophysicsCancerBiochemistryBiologyOrganic chemistryPhysicsGeneticsQuantum mechanicsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics