Bcl-6-directed follicular helper T cells promote vascular inflammatory injury in diabetic retinopathy
Yan Liu, Ziqi Yang, Peilong Lai, Zijing Huang, Xiaowei Sun, Tian Zhou, Chang He, Xialin Liu
Abstract
: Our results suggested that excessive Bcl-6-directed Tfh cells represent an unrecognized feature of DR and be responsible for the retinal vascular inflammation and angiogenesis, providing opportunities for new therapeutic approaches to DR.
Topics & Concepts
Diabetic retinopathyMedicineFollicular phaseInflammationImmunologyInternal medicineDiabetes mellitusEndocrinologyNeuroinflammation and Neurodegeneration MechanismsRetinal Diseases and TreatmentsAtherosclerosis and Cardiovascular Diseases