Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019
Jianghong Fan, Xinyuan Zhang, Jiang Liu, Yuching Yang, Nan Zheng, Qi Liu, Kimberly Bergman, Kellie S. Reynolds, Shiew‐Mei Huang, Hao Zhu, Yaning Wang
Abstract
Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.
Topics & Concepts
HydroxychloroquineMedicineIn vivoIn vitroCoronavirus disease 2019 (COVID-19)CoronavirusVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pharmacology2019-20 coronavirus outbreakDiseaseInternal medicineInfectious disease (medical specialty)BiologyOutbreakBiochemistryBiotechnologyInfectious Encephalopathies and EncephalitisCOVID-19 Clinical Research StudiesDrug-Induced Ocular Toxicity