Sialic Acid Binding Sites in VP2 of Bluetongue Virus and Their Use during Virus Entry
Weining Wu, Polly Roy
Abstract
To date no receptor has been assigned for non-enveloped bluetongue virus. To determine if the outermost spike-like VP2 protein is responsible for host cell attachment via interaction with sialic acids, we first generated a protein-based VP2-nanoparticle, for the multivalent presentation of recombinant VP2 protein.
Topics & Concepts
BiologyOrbivirusCapsidVirusViral entryVirologyGlycanCulicoidesViral replicationGlycoproteinBiochemistryReoviridaeRotavirusEcologyVector-Borne Animal DiseasesViral Infections and VectorsViral gastroenteritis research and epidemiology