Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients
Anne‐Grete Märtson, Kim C. M. van der Elst, Anette Veringa, Jan G. Zijlstra, Albertus Beishuizen, Tjip S. van der Werf, Jos G. W. Kosterink, Michael Neely, Jan‐Willem C. Alffenaar
Abstract
A loading dose of 2 mg/kg on the first day, followed by 1.25 mg/kg as a maintenance dose, was chosen. With this dose, 98% of the patients were expected to reach the AUC target on the first day and 100% of the patients on the third day. The registered caspofungin dose might not be suitable for critically ill patients who were all overweight (≥120 kg), over 80% of median weight (78 kg), and around 25% of lower weight (≤50 kg). A weight-based dose regimen might be appropriate for achieving adequate exposure of caspofungin in intensive care unit patients.
Topics & Concepts
DosingPharmacokineticsMedicineCaspofunginPopulationRegimenPopulation pharmacokineticsPharmacologyInternal medicineVoriconazoleAntifungalEnvironmental healthDermatologyAntifungal resistance and susceptibilityHelminth infection and controlCystic Fibrosis Research Advances