Design of an activatable NIR-II nanoprobe for the <i>in vivo</i> elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations
Yi Lai, Yijing Dang, Qian Sun, Jiaxing Pan, Haijun Yu, Wen Zhang, Zhiai Xu
Abstract
detection of MGO with a 24.2-fold enhancement in NIR-II fluorescence intensity compared with wild-type mice. Thus, this MGO-activated NIR-II-emitting nanoprobe is potentially useful for early AD diagnosis in clinic.
Topics & Concepts
NanoprobeIn vivoFluorescenceBiophysicsChemistryMethylglyoxalPreclinical imagingBlood–brain barrierNear-infrared spectroscopyBiochemistryBiologyCentral nervous systemNeurosciencePhysicsQuantum mechanicsEnzymeBiotechnologyAdvanced Glycation End Products researchBiochemical effects in animalsSulfur Compounds in Biology