Tunable C–H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis
Kang Rui Xiang, Shuo Zhang, Long Liu, Tianzeng Huang, Zhi Tang, Chunya Li, Kaiqiang Xu, Tieqiao Chen
Abstract
Direct C–H arylation and acylation of azoles with carboxylic acids are achieved selectively through Pd/Cu cooperative catalysis: biaryls are generated selectively with dppp as ligand, while biaryl ketones are obtained with high selectivity using dpph or Ph<sub>2</sub>PCy as ligand.
Topics & Concepts
ChemistryAcylationCatalysisLigand (biochemistry)SelectivityCarboxylic acidOrganic chemistryCombinatorial chemistryMedicinal chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques