In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman, Peter M. Allen, Kira E. Olander, Kyle Ockerman, Clara Wolfe, Fabius Wiesmann, Nelson H. Knudsen, Hsiao‐Wei Tsao, Arvin Iracheta‐Vellve, Emily M. Schneider, Andrea N. Rivera-Rosario, Ian C. Kohnle, Hans W. Pope, Austin Ayer, Gargi Mishra, Margaret D. Zimmer, Sarah Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T. Frederick, Genevieve M. Boland, W. Nicholas Haining, David E. Root, John G. Doench, Nir Hacohen, Kathleen B. Yates, Robert T. Manguso
Topics & Concepts
Immune systemImmune checkpointBiologyMajor histocompatibility complexMHC class ICD8Downregulation and upregulationCancer researchImmunotherapyImmunologyCancer immunotherapyGeneGeneticsImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research