Polypeptoids and Peptoid–Peptide Hybrids by Transition Metal Catalysis
Zachary S. Clauss, Jessica R. Kramer
Abstract
-carboxyanhydrides. Our method is amenable to hydrophilic and hydrophobic side chains and yields high-molecular-weight linear polypeptoids of predictable length and low dispersity. Further, the polymer end groups can be tuned for biological targeting, and polypeptide-polypeptoid hybrids are readily prepared in one pot. Our materials are indeed resistant to common proteases and are well-tolerated by human cells. Overall, this work represents a significant stride toward access to tunable polypeptoids.
Topics & Concepts
DispersityPeptoidCombinatorial chemistryMaterials scienceBiocompatibilityPolymerPolymerizationSide chainMonomerPeptideNanotechnologyChemistryPolymer chemistryOrganic chemistryBiochemistryChemical Synthesis and AnalysisClick Chemistry and ApplicationsDendrimers and Hyperbranched Polymers