Fortuneicyclidins A and B, Pyrrolizidine Alkaloids with a 7-Azatetracyclo[5.4.3.0.0<sup>2,8</sup>]tridecane Core, from <i>Cephalotaxus fortunei</i>
Li Zhu, Dong‐Rong Zhu, Wu-Xi Zhou, Jiangmin Zhu, Lijie Gong, Yin Li, Lingyi Kong, Jian‐Guang Luo
Abstract
Fortuneicyclidins A (1) and B (2), a pair of epimeric pyrrolizidine alkaloids containing an unprecedented 7-azatetracyclo[5.4.3.0.02,8]tridecane core, were isolated from the seeds of Cephalotaxus fortunei, along with two biogenetically relative known analogues, 3 and 4. The structures were determined by multiple spectral techniques and chemical derivatization methods. Compound 1 showed inhibitory activity against α-glucosidase.
Topics & Concepts
PyrrolizidineChemistryDerivatizationStereochemistryCore (optical fiber)Organic chemistryHigh-performance liquid chromatographyPhysicsOpticsBiological Activity of Diterpenoids and BiflavonoidsNatural product bioactivities and synthesisPlant Toxicity and Pharmacological Properties