Description of Druglike Properties of Safranal and Its Chemistry behind Low Oral Exposure
Ashish Dogra, Pankul Kotwal, Abhishek Gour, Shipra Bhatt, Gurdarshan Singh, Debaraj Mukherjee, Utpal Nandi
Abstract
oral absorption was found to be very poor, which is linked to the structural integrity of safranal in simulated gastric fluid, simulated intestinal fluid, plasma, and liver microsomes. Moreover, the presence of unsaturated aldehyde moiety in safranal remains in equilibrium with its hydroxylated acetal form. Further research work is required to find out the stable oral absorbable form of safranal by derivatization of its aldehyde group without losing its potency.
Topics & Concepts
SafranalChemistryIn vivoCrocus sativusLipophilicityPharmacologyMoietyDerivatizationMetaboliteBiochemistryStereochemistryCrocinChromatographyMedicineTraditional medicineBiologyMass spectrometryBiotechnologySaffron Plant Research StudiesFlavonoids in Medical ResearchNigella sativa pharmacological applications