Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation
Jiawei Sun, Jing Zou, Ying Zheng, Hao Yuan, Yuan-Ze-Yu Xie, Xiaona Wang, Tian‐Miao Ou
Topics & Concepts
Neuroblastoma RAS viral oncogene homologChemistrySide chainMelanomaMutantTranslation (biology)Cancer researchRNAStereochemistryMutationBiochemistryGeneBiologyOrganic chemistryPolymerMessenger RNAKRASDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanismsRNA Interference and Gene Delivery