Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications
Sayedeh Azimeh Hosseini, Mohammad Hossein Haddadi, Hadis Fathizadeh, Foroogh Nemati, Hooman Mahmoudi, Farima Taraj, AmirArsalan Aghabozorgizadeh, Golmaryam Gandomkar, Elaheh Bazazzadeh
Abstract
The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, particularly in the areas of cancer immunity, cancer metabolism, and cancer metastasis. This has led to the demonstration of the importance of these RNAs as prognostic, diagnostic and therapeutic agents. In this review, we provide an overview of the biological activities of lncRNAs in GC development and update the latest pathological activities, prognostic and diagnostic strategies, and therapeutic options for GC-related lncRNAs.