Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study)
Inass Hassan Ahmad, Eman Roshdy Mohamed Mostafa, Shymaa Abdelhafeez Mohammed, Walaa Shipl, Amany Ahmed Soliman, Marwa Said
Abstract
BACKGROUND: Metabolic syndrome (MetS) in men is a common problem. Several studies highlight that testosterone deficiency is associated with metabolic disorders that may be explained by "myokines". Irisin is an adipo-myokine that has beneficial metabolic effects. AIM: To evaluate serum testosterone in a sample of Egyptian men with MetS diagnosed by NCEP ATP III, and correlate it with serum irisin level. METHODS: A total of 90 men (60 with MetS and 30 healthy age-matched controls) participated in the study. Testosterone level is estimated by an automated system, Irisin level was measured by ELISA. RESULTS: Circulating irisin was positively correlated with serum testosterone and was significantly lower in patients with MetS. CONCLUSION: treatments of MetS may include testosterone supplementation. Further studies are needed to elucidate this association.