Pregnancy-related plasticity of gastric vagal afferent signals in mice
Hui Li, Georgia S. Clarke, Stewart Christie, Sharon R. Ladyman, Stephen J. Kentish, Richard L. Young, Kathryn L. Gatford, Amanda J. Page
Abstract
This study provides first evidence that gastric vagal afferent signaling is attenuated during pregnancy and inversely associated with meal size. Growth hormone attenuated mechanosensitivity of gastric vagal afferents, adding support that increases in maternal growth hormone may mediate adaptations in gastric vagal afferent signaling during pregnancy. These findings have important implications for the peripheral control of food intake during pregnancy.
Topics & Concepts
PregnancyAfferentHormoneEndocrinologyInternal medicineMedicineVagus nervePeripheralMealBiologyStimulationGeneticsRegulation of Appetite and ObesityDietary Effects on HealthBiochemical Analysis and Sensing Techniques