Discovery of multi-target directed 3-OH pyrrolidine derivatives through a semisynthetic approach from alkaloid vasicine for the treatment of Alzheimer's disease
Kancharla Bhanukiran, Gajendra T.A., Sairam Krishnamurthy, Sushil Kumar Singh, S Hemalatha
Topics & Concepts
ChemistryIn vivoPharmacologyAlkaloidLead compoundNeuroprotectionCholinesterasePropidium iodideButyrylcholinesteraseTacrineIn vitroBiochemistryStereochemistryAchéAcetylcholinesteraseEnzymeMedicineBiologyApoptosisProgrammed cell deathBiotechnologySynthesis and bioactivity of alkaloidsCholinesterase and Neurodegenerative DiseasesCoordination Chemistry and Organometallics