Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells
Frank Bearoff, Dhruva D. Dhavale, Paul T. Kotzbauer, Sandhya Kortagere
Topics & Concepts
NeuroinflammationDownregulation and upregulationCell biologySubstantia nigraSignal transductionInflammationNF-κBBiologyRELBAlpha-synucleinNFKB1ChemistryImmunologyNeuroscienceDopaminergicParkinson's diseaseDopamineGeneMedicineGeneticsTranscription factorInternal medicineDiseaseParkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling