Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution
Estelle Yau, Andrés Olivares‐Morales, Michael Gertz, Neil Parrott, Adam S. Darwich, Leon Aarons, Kayode Ogungbenro
Topics & Concepts
Physiologically based pharmacokinetic modellingCurse of dimensionalitySensitivity (control systems)Latin hypercube samplingBiological systemPartition coefficientEstimation theoryParameter spaceChemistryPharmacokineticsComputer scienceMathematicsStatisticsMonte Carlo methodChromatographyBioinformaticsBiologyEngineeringElectronic engineeringPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsStatistical Methods in Clinical Trials