Favipiravir and Zanamivir Cleared Infection with Influenza B in a Severely Immunocompromised Child
Casper K. Lumby, Lei Zhao, Macarena Oporto Espuelas, Tim Best, Helena J. Tutill, Divya Shah, Paul Veys, Rachel Williams, Austen Worth, Christopher J. R. Illingworth, Judy Breuer
Abstract
A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral samples illuminated the within-host dynamics of infection, demonstrating the effectiveness of favipiravir in this case.
Topics & Concepts
FavipiravirClearanceZanamivirMedicineVirologyImmunologyInternal medicineCoronavirus disease 2019 (COVID-19)DiseaseUrologyInfectious disease (medical specialty)Respiratory viral infections researchInfluenza Virus Research StudiesViral Infections and Outbreaks Research