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KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance

Yuangui Tang, Chenyun Dai, Huihui Yang, Xian Yang, Ziyu Chen, Jinxiu Dou, Liuxu Zhang, Tao Bai, Junfang Zheng

2025International Journal of Biological Macromolecules8 citationsDOI

Topics & Concepts

MitochondrionBiologyCitric acid cycleSIRT3Cell biologyCancer cellCytosolBiochemistryNAD+ kinaseMetabolismCancerEnzymeSirtuinGeneticsCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyEpigenetics and DNA Methylation
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance | Litcius