Novel α-mannose-functionalized poly(β-amino ester) nanoparticles as mRNA vaccines with increased antigen presenting cell selectivity in the spleen
Nil González-Ríos, Margalida Artigues, Marta Guerra‐Rebollo, Antoni Planas, Salvador Borrós, Magda Faijes, Cristina Fornaguera
Abstract
. In conclusion, we demonstrated, at a preclinical level, that the mannose functionalization enables more selective targeting of APCs and, thus, these polymer and nanoparticles are candidates for a new generation of mRNA immunotherapy vaccines.
Topics & Concepts
MannoseMannose receptorSpleenAntigenSchematicNanoparticleMessenger RNAChemistryMolecular biologyMaterials scienceImmunologyBiochemistryNanotechnologyMedicineBiologyGeneIn vitroEngineeringMacrophageElectronic engineeringImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryImmune Response and Inflammation