Ru(II)-Catalyzed C–H Alkenylation of Benzimidates with Unactivated Olefins: A Route to <i>ortho</i>-Alkenylated Benzonitriles
Chikkabagilu Nagaraju Shambhavi, Masilamani Jeganmohan
Abstract
-alkenylated benzonitriles in good to excellent yields in a highly regio- and stereoselective manner is described. In the reaction, an imidate group converted into a nitrile under the reaction conditions. The alkenylation reaction was compatible with various substituted benzimidates as well as functionalized unactivated olefins, including ibuprofen-, neproxen-, coumarin-, and cholesterol-substituted alkenes. A feasible reaction mechanism was proposed to account for the present alkenylation reaction.
Topics & Concepts
ChemistryCatalysisNitrileStereoselectivityOrganic chemistryMedicinal chemistryIbuprofenCombinatorial chemistryPharmacologyMedicineCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques