Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of <i>MMP9</i> and <i>ABCG2</i>
Ying Huang, Shanhe Yu, Wenxuan Zhen, Tao Cheng, Dan Wang, Jiebo Lin, Yuhan Wu, Yifan Wang, Yi Chen, Liping Shu, Yì Wáng, Xiao‐Jian Sun, Yi Zhou, Fan Yang, Chih-Hung Hsu, Peng‐Fei Xu
Abstract
as two potential therapeutic targets for myeloid malignant diseases.
Topics & Concepts
ZebrafishChemistryMyeloid leukemiaLeukemiaCancer researchHaematopoiesisDownregulation and upregulationMolecular biologyBiologyCell biologyGeneBiochemistryImmunologyStem cellEpigenetics and DNA MethylationAcute Myeloid Leukemia ResearchCancer-related molecular mechanisms research