Smart nanocarrier-based chitosan @silica coated carbon nanotubes composite for breast cancer treatment approach
Ahmed A. G. El‐Shahawy, Noha Elnagar, Medhat Zohery, Maha Sabry Abd Elhafeez, S.I. El‐Dek
Abstract
The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chitosan (CS). The latter possessed a unique nanostructure with pH-sensitivity in DOX release to be administered orally for the treatment of breast cancer. The loaded DOX and entrapment efficiency reached 64% and 99%, respectively. The results of MWCNTs@MS@CS@DOX confirmed its efficiency as pH-based drug delivery for oral breast cancer therapy.
Topics & Concepts
NanocarriersChitosanCarbon nanotubeMaterials scienceMesoporous silicaBioavailabilityComposite numberDrug deliveryNanocompositeNanotechnologyBreast cancerChemical engineeringChemistryCancerMedicinePharmacologyComposite materialMesoporous materialOrganic chemistryInternal medicineEngineeringCatalysisGraphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryMesoporous Materials and Catalysis