Multifocal Kaposiform Hemangioendothelioma in a Newborn With Confirmatory Histopathology
Olivia G. Cohen, Stephanie Florez-Pollack, Laura S. Finn, Mary Larijani, Melinda Jen, James R. Treat, Denise M. Adams, Michael R. Acord
Abstract
Kaposiform hemangioendothelioma is classified as a locally aggressive vascular tumor of childhood resulting from abnormal angiogenesis and lymphangiogenesis. Most commonly, KHE presents as a single tissue mass, ranging from an erythematous papule to a violaceous indurated tumor. Definitive diagnosis requires tissue sampling with the demonstration of ill-defined nodules and fascicles of spindle-shaped D2-40 positive endothelial cells, forming slit-like vascular channels. This newborn presented with multifocal cutaneous Kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon confirmed on histopathology with immunostaining.