Evaluation of nebulised dexmedetomidine in blunting haemodynamic response to intubation: A prospective randomised study
Nimmagadda R R Kumar, Nirmala Jonnavithula, Shibani Padhy, Virinchi Sanapala, Vadithe Vasram Naik
Abstract
BACKGROUND AND AIM: The process of laryngoscopy and endotracheal intubation is associated with intense sympathetic activity, which may precipitate intra-operative complications. Taking the advantage of dexmedetomidine's good bioavailability and rapid absorption through nasal mucosa; we contemplated this study to evaluate the effects of nebulised dexmedetomidine as a premedication in blunting the haemodynamic response to laryngoscopy and tracheal intubation. METHODS: = 50) received 1 μg/kg dexmedetomidine 5 ml 10 min before induction in sitting position. RESULTS: 0.002). There was a dose sparing effect of propofol in group D; sedation score was comparable. CONCLUSION: Nebulised dexmedetomidine effectively blunts the stress response to laryngoscopy and intubation with no adverse effects.