Development and optimization of a stability-indicating chromatographic method for verapamil hydrochloride and its impurities in tablets using an analytical quality by design (AQbD) approach
Camila dos Santos Moreira, Felipe Rebello Lourenço
Topics & Concepts
ChromatographyAmmonium formateImpurityAmmonium hydroxideChemistryQuality by DesignForced degradationCentral composite designHigh-performance liquid chromatographyResponse surface methodologyAcetonitrileElutionDesign of experimentsMathematicsParticle sizePhysical chemistryOrganic chemistryStatisticsAnalytical Methods in PharmaceuticalsPesticide Residue Analysis and SafetyAnalytical Chemistry and Chromatography