Cobalt-Catalyzed Enantioselective Reductive Amination of Ketones with Hydrazides
Tiantian Chen, Yanhua Hu, Xuyang Tang, Yashi Zou, Liangming Wei, Zhenfeng Zhang, Wanbin Zhang
Abstract
An efficient cobalt-catalyzed asymmetric reductive amination of ketones with hydrazides has been realized, directly producing valuable chiral hydrazines in high yields and enantioselectivities (up to 98% enantiomeric excess).
Topics & Concepts
ChemistryReductive aminationEnantioselective synthesisCobaltAminationCatalysisEnantiomerEnantiomeric excessCombinatorial chemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods