EGFRvIII tumorigenicity requires PDGFRA co-signaling and reveals therapeutic vulnerabilities in glioblastoma
Alan T. Yeo, Hyun Jung Jun, Vicky A. Appleman, Piyan Zhang, Hemant Varma, Jann N. Sarkaria, Al Charest
Topics & Concepts
PDGFRABiologyCancer researchEpidermal growth factor receptorGrowth factor receptorKinaseSignal transductionReceptorCell biologyGeneticsGiSTStromal cellGlioma Diagnosis and TreatmentNeuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism