R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage
Ourania Chatzidoukaki, Kalliopi Stratigi, Evi Goulielmaki, George Niotis, Alexia Akalestou-Clocher, Katerina Gkirtzimanaki, Alexandros Zafeiropoulos, Janine Altmüller, Pantelis Topalis, George A. Garinis
Abstract
paving the way for novel rationalized intervention strategies against age-related chronic inflammation.
Topics & Concepts
InflammationDNA damageCytoplasmDNABiologyCell biologyImmunologyGeneticsDNA Repair MechanismsPARP inhibition in cancer therapyCell death mechanisms and regulation