Novel 3,4-dihydroquinolin-2(1H)-one derivatives as dual inhibitor targeting AKR1B1/ROS for treatment of diabetic complications: Design, synthesis and biological evaluation
Zhongfei Han, Gang Qi, Junkai Zhu, Yundong Zhang, Yin Xu, Kang Yan, Changjin Zhu, Xin Hao
Topics & Concepts
ChemistryAldose reductaseTroloxReactive oxygen speciesPharmacologyAntioxidantCombinatorial chemistryBiochemistryEnzymeAntioxidant capacityMedicineAldose Reductase and TaurineAdvanced Glycation End Products researchBiochemical effects in animals