Litcius/Paper detail

Successful recovery from severe COVID‐19 pneumonia after kidney transplantation: The interplay between immunosuppression and novel therapy including tocilizumab

Andrea Lauterio, M. Valsecchi, S Santambrogio, Riccardo De Carlis, Marco Merli, Angelo Calini, Leonardo Centonze, Vincenzo Buscemi, Maurizio Bottiroli, Massimo Puoti, Roberto Fumagalli, Luciano De Carlis

2020Transplant Infectious Disease29 citationsDOIOpen Access PDF

Abstract

Although immunosuppressed patients may be more prone to SARS-CoV-2 infection with atypical presentation, long-term immunosuppression therapy may provide some sort of protection for severe clinical complications of COVID-19. The interaction between immunosuppression and new antiviral drugs in the treatment of transplanted patients contracting COVID-19 has not yet been fully investigated. Moreover, data regarding the optimal management of these patients are still very limited. We report a case of the successful recovery from severe COVID-19 of a kidney-transplanted patient treated with hydroxychloroquine, lopinavir/ritonavir, steroid, and tocilizumab.

Topics & Concepts

MedicineImmunosuppressionTocilizumabHydroxychloroquinePneumoniaLopinavirRitonavirKidney transplantationLopinavir/ritonavirCoronavirus disease 2019 (COVID-19)TransplantationImmunologyIntensive care medicineInternal medicineHuman immunodeficiency virus (HIV)Viral loadRheumatoid arthritisAntiretroviral therapyInfectious disease (medical specialty)DiseaseCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Intensive Care Unit Cognitive Disorders