Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action
Fatma A. Mohamed, Saleha Y. M. Alakilli, Eman Fawzy El Azab, Faris Baawad, Esraa Ibrahim A. Shaaban, Heba Abu Alrub, Omnia M. Hendawy, Hesham A. M. Gomaa, Adel G. Bakr, Mostafa Abdelrahman, Laurent Trembleau, Anber F. Mohammed, Bahaa G. M. Youssif
Abstract
values of 46 ± 05 nM and 33 ± 04 nM, respectively. The EGFR and CDK2 assays revealed that compounds 5i and 5j displayed potent antiproliferative activity and can be considered as potential dual EGFR and CDK2 inhibitors.
Topics & Concepts
Indole testEpidermal growth factor receptorCyclin-dependent kinase 2ChemistryKinaseDual (grammatical number)EGFR inhibitorsCancer researchStereochemistryCombinatorial chemistryPharmacologyBiochemistryBiologyReceptorProtein kinase AArtLiteratureHER2/EGFR in Cancer ResearchBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanisms