<scp>Pd‐Catalyzed</scp> Transfer of Difluorocarbene for Three Component <scp>Cross‐Coupling</scp><sup>†</sup>
Zhiwei Xu, Wei Zhang, Jin‐Hong Lin, Chuan‐Ming Jin, Ji‐Chang Xiao
Abstract
Summary of main observation and conclusion Outstanding accomplishments have been achieved in the chemistry of difluorocarbene, but transition‐ metal‐catalyzed transfer of difluorocarbene for coupling remains a challenging task. Herein, we describe a Pd‐catalyzed coupling of difluorocarbene with two aryl carbon centers to give difluoromethylenation products, which cannot be obtained by any previous difluorocarbene‐transformation method.
Topics & Concepts
DifluorocarbeneCatalysisCoupling (piping)ChemistryArylComponent (thermodynamics)PhysicsMedicinal chemistryMaterials scienceOrganic chemistryThermodynamicsAlkylMetallurgyFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions