Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions
Joseph A. Mattocks, Joseph A. Cotruvo, Gauthier J.‐P. Deblonde
Abstract
lanthanides. This study not only clarifies the essential role of coordinated solvent for LanM's physiological function and separation applications, but it also demonstrates that LanM's preference for actinides over lanthanides can be further improved. More broadly, it demonstrates how biomolecular scaffolds possess an expanded repertoire of tunable interactions compared to most small-molecule ligands - providing an avenue for high-performance LanM-based actinide/lanthanide separation methods and bio-engineered chelators optimized for specific medical isotopes.
Topics & Concepts
ActinideLanthanideCoordination sphereSelectivityChemistryCoordination complexSolventInorganic chemistryOrganic chemistryMoleculeIonCatalysisMetalRadioactive element chemistry and processingLanthanide and Transition Metal ComplexesExtraction and Separation Processes