Antiviral activity and underlying mechanisms of baicalin against avian infectious bronchitis virus <i>in vitro</i>
Haipeng Feng, Kai Zhang, Kang Zhang, Zhiting Guo, Qin Liu, Lei Wang, Xuezhi Wang, Zhengying Qiu, Guibo Wang, Jingyan Zhang, Jianxi Li
Abstract
Baicalin inhibits IBV replication by reducing IBV N protein and mRNA.Baicalin disturbs multiple stages of the IBV life cycle.Baicalin activates PKR/eIF2α pathway and induces stress granule formation to exert anti-IBV response.
Topics & Concepts
BaicalinViral replicationScutellaria baicalensisVirologyBiologyStress granuleMicrobiologyIn vitroVirusChemistryMessenger RNAMedicineBiochemistryGeneTraditional Chinese medicinePathologyHigh-performance liquid chromatographyAlternative medicineChromatographyTranslation (biology)Animal Virus Infections Studiesinterferon and immune responsesHerpesvirus Infections and Treatments