Ceratonia siliqua leaves ethanol extracts exert anti-nociceptive and anti-inflammatory effects
Abdelrahim Alqudah, Esam Qnais, Mohammed Wedyan, Muna Oqal, Mohammed Alqudah, Rawan Abudalo, Nabil N. AL‐Hashimi
Abstract
Background: leaves Methods: leaves were studied using well-established animal models of inflammation and pain. A hot plate latency assay (55 °C) was used to assess the analgesic effect of 10, 31.6, 100, and 316 mg/kg doses of ethanol extracts in addition to paw licking time in early and late phase using a formalin-induced paw licking assay test. Paw oedema induction using carrageenan and cotton pellet granuloma assays were used to assess the anti-inflammatory effect of 10, 31.6, 100, and 316 mg/kg doses of ethanol extract. Results: leaves showed the presence of tannins, alkaloids, flavonoids and terpenoids. Conclusion: leaves might possess anti-inflammatory and anti-nociception properties and should be considered for further therapeutic research.