Transition-metal-catalyzed C–H functionalization of pyrazoles
Eunsu Kang, Hyun Tae Kim, Jung Min Joo
Abstract
This review describes recent advances in transition-metal-catalyzed C-H functionalization reactions of pyrazoles to form new C-C and C-heteroatom bonds on the pyrazole ring. In contrast to traditional cross-coupling reactions that require pre-functionalized pyrazoles, direct C-H functionalization reactions provide access to a wide range of functionalized pyrazoles in a single step. Various strategies are presented and the efficiency and regioselectivity are described with respect to the types of functional groups that are installed.
Topics & Concepts
ChemistrySurface modificationRegioselectivityPyrazoleCombinatorial chemistryCatalysisHeteroatomTransition metalRing (chemistry)Coupling reactionOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCyclopropane Reaction Mechanisms