Transition-Metal-Catalyzed Remote C–H Bond Functionalization of Cyclic Amines
Weijie Chen, Xiaoyu Yang, Xi Cao
Abstract
Abstract C–H bond functionalization is one of the most effective strategies for the rapid synthesis of cyclic amines containing substituents on the ring, which are core structures of many bioactive molecules. However, it is much more challenging to perform this strategy on remote C–H bonds compared to the α-C–H bonds of cyclic amines. This graphical review aims to provide a concise overview on transition-metal-catalyzed methods for the remote C–H bond functionalization of cyclic amines. Examples are categorized and demonstrated according to mechanistic pathways that initiate the reactions of cyclic amine substrates. Where relevant, selected substrate scope and detailed reaction mechanisms are given.
Topics & Concepts
Surface modificationCyclic aminesTransition metalCatalysisAmine gas treatingCombinatorial chemistryChemistrySubstrate (aquarium)MoleculeRing (chemistry)Scope (computer science)Organic chemistryComputer scienceOceanographyPhysical chemistryProgramming languageGeologyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis